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Livedoid skin reaction and mRNA Covid-19 vaccine: correspondence
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Dear Editor,
we would like to share ideas on the publication “Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine 1.” Girolami et al. observed that no cases of a livedoid skin reaction connected with the Covid-19 vaccine had been documented, and this case demonstrates that a huge livedoid reaction can be another type of skin reaction to the mRNA Covid-19 vaccine 1. Despite its benefits, the Covid-19 vaccine may be dangerous, which concerns us all. Because there is minimal information on the health and immunological status of vaccine recipients prior to inoculation, determining the precise etiology of a clinical problem may be difficult. A clinical comorbidity could be the source of the problem detected by the Covid-19 vaccine 2. For example, it is easy to misinterpret a clinical condition caused by infection in a vaccine recipient 2. It is now too early to identify any potential detrimental effects of the Covid-19 vaccination because there is no comprehensive, accurate record of a person’s health or immunological condition prior to receiving the immunization. Finally, it should be mentioned that the livedoid skin reaction may be observed in Covid-19 3. Asymptomatic Covid-19 is not uncommon and can occur at any moment, including during vaccination or after vaccination 4. As a result, this potential clinical entity must also be ruled out.
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The authors declare no conflict of interest.
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References
- Girolami I, Eisendle K, Kluge RW, Hanspeter E, Eccher A, Vizziello L, Zampieri P, Mazzoleni G. Livedoid skin reaction to 2nd dose of mRNA Covid-19 vaccine. Pathologica. 2022; 114:322-325. DOI
- Kebayoon A, Wiwanitkit V. Dengue After COVID-19 Vaccination: possible and Might be Missed. Clin Appl Thromb Hemost. 2021; 27:10760296211047229. DOI
- Ionescu MA. COVID-19 skin lesions are rarely positive at RT-PCR test: the macrophage activation with vascular impact and SARS-CoV-2-induced cytokine storm. Int J Dermatol. 2022; 61:3-6. DOI
- Joob B, Wiwanitkit V. Letter to the Editor: Coronavirus Disease 2019 (COVID-19), Infectivity, and the Incubation Period. J Prev Med Public Health. 2020; 53:70. DOI
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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© Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology , 2023
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